Hidradenitis Suppurativa Gene Discovery

Why this research matters? 

Hidradenitis Suppurativa (HS) is a chronic dermatological condition characterised by painful nodules, abscesses, and sinus tracts that typically develop in skin folds. Individuals with HS often experience significant distress due to its impact on daily life. The exact cause of HS is complex and thought to involve genetic, immunologic, epigenetic, and environmental factors. However, the genetic contributions to HS remain poorly understood. Greater insight into the genetic basis of HS is critical to improving diagnosis, treatment, and long-term management.

Study aims  

This study aims to enhance our understanding the genetic factors contributing to HS by analysing family history information and conducting genetic analysis. By identifying genes associated with HS, we aim to better understand how the condition develops and progresses, as well as improve management and treatment options. Findings may also help inform risk assessment and care strategies for affected individuals and their families.

What we have achieved so far 

We are in the final stages of recruitment, collecting saliva samples and family history information from individuals affected by HS, as well as from eligible family members. Once sample collection is complete, we will begin analysing the genomic data.

Current research updates 

  • We are conducting detailed discussions with patients and our research genetic counsellor to gather comprehensive family history information.

  • Saliva samples are being collected from eligible participants for genomic testing and analysis.

What’s next? Future research areas  

  • Conduct genomic testing and analysis of eligible participants to identify common patterns that may reveal potential genetic contributors to HS.

  • Prepare and publish findings to contribute to the scientific literature in this underrepresented area of dermatological genomic research.

Staying up to date  

If you’re interested in learning more about this research or getting involved, please contact us:

📩 igmgenomics@uq.edu.au

Who is working on this study?